and Arthritis Information - benefit and side effects, natural and alternative
treatment, dosage, 500 mg and 1500 mg and use with chondroitin
Joint Power Rx with Glucosamine Sulfate Formulated by a medical doctor. This powerful formula includes several additional herbal extracts and nutrients that play a role in joint health.
Joint Power Rx supplement has: Glucosamine sulfate, chondroitin sulfate, MSM, CMO complex, boswellia serrata extract, curcumin and turmeric, cat's claw extract, devil's claw extract, grape seed extract, and sea cucumber.
See the exact ingredient dosages, to buy Joint Power Rx, glucosamine sulfate, chondroitin sulfate
and osteoarthritis nutritional and nutraceutical treatment
Glucosamine has hardly been evaluated in conditions other than osteoarthritis. Hence it is not clear whether it is helpful in those with damage to cartilage or joints due to musculoskeletal injuries. It appears to help rebuild cartilage in arthritis patients, but it is unlikely that it would help joints where the cartilage has been surgically removed. Similarly, it has not been tested in autoimmune diseases involving joints such as lupus and rheumatoid arthritis. Those with artificial joints are not likely to be helped by glucosamine since they have no cartilage.
After a glucosamine supplement is taken by mouth, it makes itself into the bloodstream and in joints. The positive effects of supplementation in reducing joint pain are often noticed within a few weeks.
There is disagreement in the medical community regarding the health benefits of glucosamine and whether this nutrient is helpful in reducing symptoms of arthritis and reducing joint pain. Most studies indicate that it does play a role in improving symptoms of arthritis.
Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling.
Eur Radiol. 2009. Radiology Department, Dr Peset University Hospital, Valencia, Spain.
Sixteen patients with patella degeneration, were randomly distributed into glucosamine sulfate or control groups. In the glucosamine group, pain and functional outcomes statistically improved. Glucosamine sulfate decreased pain while improving functional outcome in patients with cartilage degeneration.
I understand glucosamine is of benefit to those with regular degenerative arthritis, but does it benefit those with rheumatoid arthritis?
We doubt glucosamine would benefit patients with rheumatoid arthritis since the joint damage is due to an autoimmune reaction. However, we can't be sure until studies are completed.
Formulas for arthritis and osteoarthritis
Arthred Arthritis formula with hydrolyzed collagen without a prescription
Hylan G F 20 intra articular injection benefit and side effects for osteoarthritis. Hylan GF20 is only available by prescription.
Inflama-Rest Cox-2 Inhibitor, by Source Naturals with high quality herbs
N.A.G. N acetyl glucosamine supplement is available over the counter
Perna Canaliculus oil extract is used for arthritis treatment and is known by the product name Lyprinol.
Glucosamine sulfate or hydrochloride?
Glucosamine is available as sulfate or hydrochloride (hcl). Almost all of the studies have used the sulfate form since a company in Europe funded the studies, and we know that it works. However, the hydrochloride form has been used by doctors for many years and it seems to work just as well. The hydrochloride form is cheaper.
is an allergy response possible?
Those who are allergic to sulfates may take glucosamine hydrochloride and not glucosamine sulfate, and they should avoid chondroitin sulfate. Glucosamine is derived from shrimp, oyster and crab shells and chondroitin is derived from cartilage of cows, pigs, and sharks. There is no synthetically made glucosamine on the market.
Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?
Clin Exp Allergy. 2006. Tulane University Health Sciences Center, Department of Clinical Immunology, Allergy, and Rheumatology, New Orleans, LA, USA.
There is concern that shrimp-allergic individuals may react to glucosamine-containing products as shrimp shells are a major source of glucosamine used for human consumption. The purpose of this study was to determine whether shrimp-allergic individuals can tolerate therapeutic doses of glucosamine. Subjects with a history of shrimp allergy were recruited and tested for both shrimp reactivity via a prick skin test and shrimp-specific IgE by an ImmunoCAP assay. Fifteen subjects with positive skin tests to shrimp and an ImmunoCAP class level of two or greater were selected for a double-blind placebo-controlled food challenge using glucosamine-chondroitin tablets containing 1,500 mg of synthetically produced (control) or shrimp-derived glucosamine. Immediate reactions, including changes in peak flow and blood pressure, and delayed reactions (up to 24 h post-challenge) via questionnaire were noted and assessed. All subjects tolerated 1,500 mg of both shrimp-derived or synthetic glucosamine without incident of an immediate hypersensitivity response. Peak flows and blood pressures remained constant, and no subject had symptoms of a delayed reaction 24 h later. This study demonstrates that glucosamine supplements from specific manufacturers do not contain clinically relevant levels of shrimp allergen and therefore appear to pose no threat to shrimp-allergic individuals.
Combining with over the counter and prescription drugs
Glucosamine may be taken together with acetaminophen or NSAIDs such as ibuprofen and naproxen. After glucosamine starts working in a few weeks, hopefully the dose of the drugs can be reduced or eliminated.We are not aware of it interacting negatively with other medicines.
Glucosamine side effects, risk, danger, safety, toxicity
As of 2013, based on our current understanding, glucosamine has few adverse reactions, and can be taken for extended periods, months and years. Thus far, after being on the market for quite a number of years, there have not been any reports in the medical literature of any significant glucosamine side effects. However, as with most nutrients and medicines, long term effects are not clearly known.
We know that NSAIDs can cause stomach ulcers and bleeding. A 1991 study published in the journal Drug Research showed glucosamine to be safe. When daily oral doses of GS up to 2700 mg/kg were given in the rat and 2100 mg/kg in the dog for one year and six months, respectively, no anatomical lesions were found in the gastrointestinal system or other organs. The dose given to the dogs would be equivalent to 150,000 mg in a 70 kg human. Most of the recommended dosages for patients with arthritis are about 500 mg three times a day. However, Italian researchers have found that the LD50 (the lethal dose at which half of the animals die) of GS is 8000 mg/kg. In humans this would be equivalent to ingesting over 500,000 mg at one time or 1,000 pills each containing 500 mg.
Apparently glucosamine does not seem to influence blood levels of cholesterol.
The effect of glucosamine sulfate on the blood levels of cholesterol or triglycerides
Ugeskr Laeger. 2007.
This study was conducted in order to determine if glucosamine sulfate taken by patients as treatment for chronic joint pain influences the fasting blood levels of cholesterol and triglycerides. A study performed with parallel groups of 66 patients over 40 years of age with joint pain of long duration receiving either recommend dosage (1500 mg per day) of glucosamine sulfate or placebo. No significant differences between the two groups were found with respect to cholesterol and triglycerides were observed. There were no differences between the treatment groups with respect to side-effects. This study demonstrates that glucosamine sulfate does not significantly influence blood levels of cholesterol or triglycerides.
Diabetes blood sugar control
Glucosamine supplements, at commonly consumed doses, do not have significant effects on glycemic control, cholesterol and lipid profile, or levels of apoAI in patients with diabetes. We are not aware of any significant changes to blood sugar resulting from glucosamine ingestion. The dose, one or two grams a day, is minimal as a sugar source compared to the amounts of carbohydrates found in the foods we consume.
In a study published in Archives of Internal Medicine, 38 elderly patients with type 2 diabetes were divided into two groups. The first group took 1500 mg of glucosamine a day combined with 1200 mg of chondroitin sulfate. Chondroitin is another supplement often used in combination with glucosamine to treat osteoarthritis. The other group took placebo pills. Two-thirds of the dose was taken in the morning and one-third in the evening. The study lasted for 90 days. Blood studies were done to evaluate blood sugar levels, and also levels of hemoglobin A1c, a specific blood marker than can tell us average blood sugar levels over long periods of time. There was no statistically significant rise in hemoglobin A1c levels in those who took glucosamine.
Patients with diabetes are often at risk from toxic effects from many of the current treatments for osteoarthritis, such as the NSAIDs like ibuprofen or naprosyn. These medicines cause stomach ulcers and kidney damage if used for prolonged periods. Glucosamine provides a safer and more natural alternative.
Timing of ingestion
It's difficult to say when the best time or frequency to take it, whether with or without food, but a good option is to take this nutrient before meals. All 1,500 mg a day can be taken at one time or split in two or three divided doses throughout the day. Some research indicates taking all the pills at one time on an empty stomach may work better but if you get stomach upset taking them all at one time, consider splitting them into two or three times throughout the day.
Availability online, in health food stores, pharmacies, food stores
Most often glucosamine is sold as sulfate or hydrochloride. Very frequently glucosamine and chondroitin are combined together. Lately, more products are being sold along with MSM. Furthermore, more recently, these last three nutrients have been combined with other herbs and nutrients that play a role in joint health including CMO, curcumin, boswellia, etc. If glucosamine itself is not helpful in relieving arthritic symptoms, it may be combined with chondroitin and other nutrients. Alternatively, they can be started together with several other nutrients.
Glucosamine is also sold as a liquid and glucosamine formulas for dogs are also found in stores, where you can also find a cream form.
Does a glucosamine tablet absorb faster
than a capsule?
We doubt there would be much of an absorption difference.
What is glucosamine complex?
We are not sure what the word complex means in terms of glucosamine. We have not seen this word used in the medical literature.
Various supplement companies now make glucosamine available in liquid form. This may be appropriate for those who are not able to swallow capsules.
Would you discuss the benefits or lack
thereof from taking glucosamine
in liquid form rather than as a
pill? There is quite a bit of controversy going on regarding glucosamine
liquid versus glucosamine pills.
As of 2013, we have not seen studies with glucosamine liquid compared to glucosamine pills. Therefore, we can't say whether glucosamine liquid is any more or less effective than glucosamine pills.
Does glucosamine powder offer benefit for arthritis more than an oral
We have not seen any research comparing powder to oral glucosamine pills. We doubt the powder offers any advantages except to those who have difficulty swallowing pills.
How does glucosamine work?
Scientists still don't have all the answers, but they think glucosamine stimulates the biosynthesis (production) of some proteoglycans, restores damaged chondrocytes (cells of cartilage tissue), and has some anti-inflammatory abilities. The anti-inflammatory abilities of glucosamine are much less than NSAIDs and glucosamine is not known to have pain-killing abilities. Therefore, users should not expect immediate relief of their symptoms.
Studies on cartilage have shown anti-inflammatory effects of glucosamine related to inhibition of inflammatory mediators. Glucosamine can suppress the IL-1beta-mediated activation of synoviocytes (such as IL-8-, nitric oxide- and PGE(2)-production, and phosphorylation of p38 MAPK), thereby possibly exhibiting antiinflammatory actions in arthritis.
in chondrocytes - benefit for arthritis
Glucosamine sulphate reduces oxidative stress on chondrocytes by increasing haem oxygenase. Treatment with sulfated glucosamine to human chondrocytes and macrophages inhibits radical simulated oxidation of membrane lipids, proteins and DNA in a dose-dependent manner.
Glucosamine hydrochloride inhibits COX-2 activity by preventing COX-2 co-translational N-glycosylation and by facilitating COX-2 protein turnover during translation in a proteasome-dependent manner.
A synergistic effect can be expected when glucosamine is combined with boswellic acids ( found in the herb boswellia).
Can I find
glucosamine in foods?
No food sources of glucosamine are known that would provide this nutrient in the dosages required for arthritic relief. Hence, the best source of glucosamine is through taking supplements.
Can a women who is pregnant use glucosamine safely? Limited data indicate that glucosamine is safe to use by pregnant women.
Glucosamine use in pregnancy: an
evaluation of pregnancy outcome.
J Womens Health 2007. Division of Clinical Pharmacology, The Hospital for Sick Children, The University of Toronto, Canada.
Our objective was to determine whether glucosamine treatment in pregnancy is associated with an increased risk of major malformations or other adverse outcomes. Pregnant women were recruited from The Motherisk Program at the Hospital for Sick Children, Toronto, Canada. Women exposed to glucosamine were compared with women exposed to nonteratogenic agents. We were able to ascertain the outcomes of 54 women who used glucosamine during pregnancy (34 during organogenesis). There were 50 live births (two sets of twins), 4 spontaneous abortions, 1 therapeutic abortion, and 1 stillbirth, with no major malformations. These limited data suggest no increased risk for major malformations or other adverse fetal effects following the use of glucosamine during pregnancy.
There are more than 120 kinds of arthritis and musculoskeletal disorders exist, the most common being osteoarthritis, rheumatoid arthritis, and osteoporosis.
Because of the pain, fatigue, and joint stiffness associated with arthritis, physical intimacy may be difficult. These symptoms can be ameliorated during sexual activity by good communication between the partners, timing medication, and experimenting with different positions. The regular use of glucosamine and other natural supplements can help reduce the pain of arthritis in many patients.
Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases. Glycyrrhetinic acid is a triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which is found in the herb licorice. Glycyrrhetinic acid is also as a major metabolite of glycyrrhizin.
What do you think of the combination of Lyprinol in addition to glucosamine for arthritis
We have not seen any studies that have combined Lyprinol with glucosamine, but we don't see any major safety issues with this combination. Glucosamine is a safe nutrient that can be combined with many different herbs and nutritional supplements.