Glycyrrhizic acid health benefit and side effects

Glycyrrhizic acid (18beta-GL or GL) is a herbal extract with a broad spectrum of antiviral activities and pharmacological effects and multiple sites of action. Glycyrrhetinic acid is a hydrolysis product of glycyrrhizic acid, one of the main constituents of licorice root.

Glycyrrhizic acid and EBV
Glycyrrhizic acid inhibits Epstein-Barr virus (EBV) infection in vitro by interfering with an early step of the EBV replication cycle.

Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells.
J Pharm Pharmacol. 2008 May. Hawthorne S, Gallagher S. School of Pharmacy, Medical Biology Centre, Queens University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Glycyrrhetinic acid is the active metabolite of glycyrrhizic acid, one of the components of liquorice extract. It has been shown to possess anti-inflammatory activity and to inhibit hepatic tumour growth. In this preliminary study, we have shown that Glycyrrhetinic acid could significantly reduce the rate of proliferation of LNCaP androgen dependent prostate cancer cells, whereas it had no effect on proliferation of PC3 and DU145 androgen-independent prostate cancer cells. Additionally, Glycyrrhetinic acid could significantly reduce the production of prostate-specific antigen by LNCaP cells maintained in-vitro.

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