Glucosamine MSM combination in joint formula natural products - MSM stands for Methyl Sulphonyl Methane

MSM is a natural supplement used by many patients with osteoarthritis. MSM has antioxidant properties.

As of March 2010, we cannot find human studies published with a combination pill that has glucosamine and msm.

MSM for horses
The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise.
Acta Vet Scand. 2008 Nov 7; Marañón G, Muñoz-Escassi B, Manley W, García C, Cayado P, de la Muela MS, Olábarri B, León R, Vara E. Horsepital SL, Madrid, Spain. Exercise Methyl Sulphonyl Methane, better known as MSM, is a naturally occurring sulphur compound with well-known antioxidant properties. On the other hand, Vitamin C is important in limiting free radical damage in the aqueous phase of the cell, and cellular vitamin C status may be linked to the mechanisms involved in quenching cellular reactive oxygen species. The aim of this study was to determine if supplementation with MSM and vitamin C could alleviate exercise-induced oxidative stress in horses undergoing jumping competition. Our results suggest that jumping exercise could induce harmful effects on horses, probably due to an increase in oxidative damage and proinflammatory molecules. In addition, we have demonstrated that MSM could exert some protective effect on oxidative and inflammatory exercise-induced injury.

MSM review article
Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane MSM in the treatment of osteoarthritis.
Osteoarthritis Cartilage. 2008 Nov; Brien S, Prescott P, Bashir N, Lewith H, Lewith G. Department of Primary Care, University of Southampton, UK.
The objective of this systematic review is to evaluate the existing evidence from randomised controlled trials of two chemically related nutritional supplements, dimethyl sulfoxide (DMSO) and methylsulfonylmethane MSM in the treatment of osteoarthritis to determine their efficacy and safety profile. No definitive conclusion can currently be drawn for either supplement. The findings from all the DMSO studies need to be viewed with caution because of poor methodology including; possible unblinding, and questionable treatment duration and dose. The data from the more rigorous MSM trials provide positive but not definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee. Further studies are now required to identify both the optimum dosage and longer-term safety of MSM and DMSO, and definitive efficacy trials.

Joint Power Rx Formulated by Ray Sahelian, M.D.
Because joint pain is so debilitating, glucosamine sulfate and chondroitin sulfate alone are often not enough. This powerful joint formula includes several additional herbal extracts and nutrients including MSM, CMO, boswellia serrata, turmeric, cat's claw extract, grape seed extract, and sea cucumber for optimal joint health.  

Joint Power Rx Supplement has:
Glucosamine sulfate (from shellfish) - glucosamine is a popular ingredient in many joint health products
Chondroitin sulfate - chondroitin is a popular ingredient in many joint health products
MSM nutrient which stands for methylsulfonylmethane
CMO complex also known as cetyl myristoleate
Boswellia serrata extract is used in Ayurvedic medicine
Turmeric is an herb that contains curcumin
Cat's claw extract comes from the Amazon jungle
Devil's claw is a plant widely used in South African traditional medicine,
Grape seed extracts have compounds called procyanidolic oligomers which are powerful antioxidants, perhaps much greater than vitamins C and E.
Sea cucumbers have a number of substances that have therapeutic value.

We are not aware of a glucosamine MSM product with only these two nutrients together. Glucosamine and MSM are often combined with several other nutrients in joint health formulas such as chondroitin and CMO.

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