Perna Canaliculus oil extract for use as an anti inflammatory supplement, product name is Lyprinol and it is available without a prescription

Perna Canaliculus oil extract is used for arthritis treatment. This product is also known by the brand name Lyprinol.

A lipid extract of Perna canaliculus affects the expression of pro-inflammatory cytokines in a rat adjuvant-induced arthritis model.
Eur Ann Allergy Clin Immunol. 2008 Dec; State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen and Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
As published initially in this same journal in 2000, the lipid extract of Perna canaliculus (New Zealand green-lipped mussel; Lyprinol) is known for its anti-inflammatory effects in animal models and in human controlled studies (arthritis; asthma). As a follow-up of its effects on pain in a rat model of adjuvant-induced arthritis (ALA), we studied its effects on the production of cytokines known to be associated with inflammation (IL-6, IL-1alpha TNF-alpha, IFN-gamma). Feeding with Perna canaliculus lipid extract was associated with significantly decreased expression levels of TNF-alpha and IFN-gamma when compared to Naproxen (positive control) and, even more when compared with sham and extra-virgin olive oil (negative control). When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-1alpha were also marginally decreased in rats fed with Perna canaliculus lipid extract. This study demonstrates that AIA rats fed with Perna canaliculus lipid extract had decreased production of cytokines associated with inflammation.

Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus).
Evid Based Complement Alternat Med. 2007 Oct 29. Hielm-Björkman A, Tulamo RM, Salonen H, Raekallio M. Faculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, PO Box 57, FI-00014, Finland
A Perna canaliculus preparation was evaluated in a randomized, double-controlled and double-blinded clinical trial. It was hypothesized that the treatment effect would be less than that of the positive control (carprofen) but more than that of the negative control (placebo). Forty-five dogs with chronic pain and a radiographic diagnosis of osteoarthritis that were randomly allocated into one of three groups completed the study. All dogs were fed the Perna canaliculus or carprofen products or placebo for 8 weeks. Intake of extra carprofen was also evaluated. There were more dogs in the Perna canaliculus than in the placebo group that improved. The extent of improvement was significantly different between the Perna canaliculus and the control in veterinary-assessed mobility and pain. In conclusion, Perna canaliculus alleviated chronic orthopedic pain in dogs although it was not as effective as carprofen. As no side-effects were detected, Perna canaliculus may be beneficial in dogs e.g. when non-steroidal anti-inflammatory drugs cannot be used.